Substantial progress has been made in identifying the putative precursor lesions for ovarian cancers. We have recently learned that most advanced-stage, high-grade serous ovarian cancers originate in the fallopian tube and less aggressive endometrioid and clear cell ovarian cancers develop from pre-existing pelvic endometriosis. However, understanding how these precursor lesions develop into invasive disease with metastatic potential is an important unmet need that will facilitate improvements in prevention and early detection of ovarian cancer.
In this study, we will apply novel methods to determine the role of the tumor microenvironment in malignant transformation, novel capture methods for early detection, function of stem cells in precursor induction, and high-dimensional multi-omic characterization and integration of precursor lesions. These approaches should profoundly advance our understanding of early detection and prevention.